Patologicheskaya Fiziologiya i Eksperimentalnaya Terapiya
[Effect of selective activation and blockade of the central dopaminergic system on the course of the early post-traumatic period].
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Keywords
Abstract
Acute experiments on white rats traumatized according to Kenon demonstrated that the central administration of the dopamine receptor agonist apomorphine led a reduction in mortality rates and an increase in stroke and heart indices. The latter was due to the significant activation of the hypothalamo-hypophysis-thyroidal system. The use of sulpiride as a specific dopamine receptor blocker increased mortality rates and decreased stroke and heart indices. This was accompanied by the maximum activation of the hypothalamo-neurohypophyseal system.