Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 1997-Sep

[Effects of Andrographis paniculata component on nitric oxide, endothelin and lipid peroxidation in experimental atherosclerotic rabbits].

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H W Wang

H Y Zhao

S Q Xiang

ARTICLE: 10322878

BioSeek: 10322878

Keywords

superoxide dismutase

guanosine

albumin

andrographis

andrographis paniculata

Abstract

OBJECTIVE

To observe the effects of Andrographis Paniculata component (API0134) on nitric oxide (NO), endothelin (ET), cyclic guanosine monophosphate (cGMP), lipid peroxide (LPO) and superoxide dismutase (SOD) in experimental atherosclerotic rabbit.

METHODS

An atherosclerotic rabbit model was established by feeding high cholesterol diet supplemented by bovine serum albumin injection bolus. The rabbits were randomly divided into the control, model, and API0134 treated group. Blood samples were collected before 4 weeks and 8 weeks after relevent treatment.

RESULTS

Before 4 and after 8 weeks API0134 administration, compared with model group, the NO, cGMP and activity of SOD increased (P < 0.01), while LPO and ET decreased (P < 0.01).

CONCLUSIONS

API0134 possesses the effects of antioxidation, preserving endothelial function, and maintaining the balance of NO/ET.