Planta Medica 1996-Oct
Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
Only registered users can translate articles
Log In/Sign up
The link is saved to the clipboard
Keywords
Abstract
A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.