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Phytochemistry 2014-Sep

γ-Hydroxynitrile glucosides from the seeds of Prinsepia utilis.

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Bin Guan
Tao Li
Xi-Ke Xu
Xu-Feng Zhang
Pan-Lei Wei
Cheng-Cheng Peng
Jian-Jun Fu
Qi Zeng
Xiang-Rong Cheng
Shou-De Zhang

Keywords

Abstract

γ-Hydroxynitrile glucosides (prinsepicyanosides A-E) were isolated alongside 11 known compounds from seeds of Prinsepia utilis Royle. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The relative configuration of prinsepicyanoside C was established by Cu-Kα X-ray crystallography. Prinsepicyanoside A, osmaronin, and 4-(hydroxylmethyl)-5H-furan-2-one exhibited borderline antibacterial activity against Salmonella gallinarum, Vibrio parahaemolyticus, and Vibrio cholera with MIC values of 30.1, 20.7, and 22.8μg/mL, respectively.

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