Bioorganic and Medicinal Chemistry Letters 1999-Apr
Immunostimulation by plant polyphenols: a relationship between tumor necrosis factor-alpha production and tannin structure.
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Keywords
Abstract
The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1beta and TNF-alpha from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin beta-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-alpha rather than IL-1beta is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an ealier proposal.
