Oncology 1990
Induction of tumor necrosis factor in human peripheral-blood mononuclear cells by proteolytic enzymes.
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Keywords
Abstract
We could demonstrate that polyenzyme preparations as well as bromelain and papain stimulate the production of tumor necrosis factor-alpha in human peripheral-blood mononuclear cell cultures in a time-dependent manner. We give evidence that immunomodulation and especially the release of cytokines may contribute to the therapeutic effect of these preparations.