Current Opinion in Pharmacology 2006-Aug

Inhibition of poly(ADP-ribose) polymerase in cancer.

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Elizabeth Ruth Plummer

ARTICLE: 16753340

DOI: 10.1016/j.coph.2006.02.004

BioSeek: 16753340

Keywords

Abstract

Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA repair defects. As a result, potent PARP-1 inhibitors have in the past three years entered early clinical trials in cancer patients, and the final results of these trials are eagerly awaited.

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Inhibition of poly(ADP-ribose) polymerase in cancer.

Keywords

ribose

neoplasms

Abstract

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