Journal of Natural Products

Inhibition of tumor-promoter-enhanced 3H-choline incorporation into cellular phospholipids by phloroglucinol derivatives from Mallotus japonicus.

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M Arisawa

A Fujita

N Morita

T Okuyama

H Nishino

ARTICLE: 1800639

BioSeek: 1800639

Keywords

Abstract

The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.

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Inhibition of tumor-promoter-enhanced 3H-choline incorporation into cellular phospholipids by phloroglucinol derivatives from Mallotus japonicus.

Keywords

phloroglucinol

phospholipid

mallotojaponin

neoplasms

mallotus

anticancer

Abstract

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