New Patent on Electrospinning for Increasing of Rutin Loading in Nanofibers.

The electrospinning and the bubble electrospinning provide facile ways for fabrication of functional nanofibers by incorporating rutin/hydroxypropyl-β-cyclodextrin inclusion complex (RT/HP-β-CD-IC) in polyvinyl alcohol (PVA).The study aimed at increasing the loading amount of rutin in the electrospun nanofibers to obtain ultraviolet resistant property Method: Rutin was encapsulated in the cavity of RT/HP-β-CD and formed inclusion complex. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimeter (DSC) were used to verify the formation of inclusion complexes.The results showed that the inclusion between rutin and HP-β-CD had been were successfully formed. The surface morphologies of nanofibrous membranes were characterized by scanning electron microscope (SEM), which indicated that adding RT/HP-β-CD inclusion complexes had little influence on the morphologies and diameters of the fibers. Ultraviolet resistant results also confirmed the inclusion complex had increased the loading amount in the final nanofibrous mats, and thus had good ultraviolet resistant properties.The formed inclusion complexes had obviously enhanced the loading amount of rutin in electrospun PVA nanofibers, indicating the encapsulation of rutin in the cavity of HP-β-CD is a good way to increase the loading amount.