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Fitoterapia 2017-Mar

New phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti-inflammatory activity.

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Hai Jiang
Liu Yang
Guo-Xu Ma
Xu-Dong Xing
Mei-Ling Yan
Yan-Yan Zhang
Qiu-Hong Wang
Bing-You Yang
Hai-Xue Kuang
Xu-Dong Xu

Keywords

Abstract

The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as xanthiumnolics A-E (1-5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC50 value of 8.73μM.

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