British journal of pharmacology and chemotherapy 1964-Apr
ON THE ANTI-INFLAMMATORY ACTIVITY OF SOME SUBSTITUTED PHENOLIC COMPOUNDS.
Only registered users can translate articles
Log In/Sign up
The link is saved to the clipboard
Keywords
Abstract
Some substituted dihydroxybenzenes have been examined for suppression of the yeast-induced inflammatory reaction in the rat paw. This anti-inflammatory activity is greatest in those compounds derived from resorcinol and in particular the halogenated 5-methylresorcinols. The significance of the internuclear distance between the hydroxyl groups in the meta-position to each other in resorcinol and the importance of the enhanced activity due to the halogen atom(s) is discussed. In this series the toxicity and activity could not be divorced.