Journal of Neuro-Oncology 1996-Dec
Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor.
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Abstract
Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.