[Photosensitization of dicoumarol on tumor cells and enhancement by sodium diethyldithiocarbamate].

OBJECTIVE

To study the photosensitization of dicoumarol (Dic) on tumor cells and any effect by sodium diethyldithiocarbamate (DDC).

RESULTS

Dic, 40, 80, 120 mumol.L-1 concentration-dependently inhibited the DNA synthesis (81%-93%) and increased the mortality (50%-70.4%) of ascitic hepatoma (Hep A) cells exposed in light. These 2 indices were changed slightly by Dic alone even in non-illuminating group. DDC enhanced the photosensitization of Dic group.

CONCLUSIONS

Photosensitization of Dic showed strong antitumor activities against Hep A cells. The mortality of Hep A and inhibition of the DNA synthesis in Dic-DDC-light group significantly stronger than in Dic-light group. Photosensitization of Dic was not due to 1O2 and OH., but closely related to O2.- and H2O2.