Journal of Natural Products
Plant anticancer agents, XLVI. Cytotoxic casbane-type constituents of Agrostistachys hookeri.
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Keywords
Abstract
In addition to the previously characterized agrostistachin, three additional cytotoxic macrocyclic casbane-type diterpenes were isolated from a CHCl3 extract of Agrostistachys hookeri, by bioactivity-guided fractionation using the P-388 lymphocytic leukemia cell culture system. These novel compounds, 14-dehydroagrostistachin, 17-hydroxyagrostistachin, and agroskerin, identified by spectral data comparison to agrostistachin and demonstrated ED50 values of 2.8, 0.8, and 1.4 micrograms/ml, respectively, with cultured P-388 cells.