Potent regulation of hyperglycemia in diabetic mice by autolysates from beta-mannanase-treated brewed yeast.

Diabetes mellitus is one of the most concerned chronic diseases, characterized by hyperglycemia. This study applied either β-mannanase-treated yeast cell autolysis supernatant (YCS) or yeast cell wall residues after the autolysis (YCR) to investigate their influence on the alleviation of diabetic status in a diabetic mice model.Intervention of either YCS or YCR exerted the function on body weight gains, blood glucose reduction and lipids composition improvement in the diabetic mice. Administration of YCS displayed more preponderant in inhibiting oxidative stress than YCR. Expressions of PPARα and CPT1α were enhanced for improving lipids biosynthesis, and Trx1 and HIF-1-α genes were noted to be down-regulated due to the activating of thioredoxin family following two interventions, indicating the processes of lipids metabolism and oxidative stress were highly involved in the attenuation of the diabetic status following the interventions. Except to YCS, the current study revealed that consumption of cell wall residue (YCR) also led to an attenuated hyperglycemia, which is associated with its rich in mineral elements, such as chromium, selenium.This study may highlight the potent of both YCS and YCR as functional ingredients in dietary formula for improving diabetic syndromes This article is protected by copyright. All rights reserved.