"Prohibitin"g CRAF/MAPK activation with rocaglamides.

Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al. show that the natural anti-tumor compounds rocaglamides target the CRAF-PHB interaction to disrupt the MAPK pathway leading to proliferation block in human leukemic cells.