Bioorganic and Medicinal Chemistry Letters 2006-Feb
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Only registered users can translate articles
Log In/Sign up
The link is saved to the clipboard
Keywords
Abstract
A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT(2) receptor subtypes are reported. The analogue which showed the highest 5-HT(2C) binding affinity (27, 1.6nM) was found to be successful in reducing food intake in rats.
