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Natural Product Research 2015

Sassarandainol: a new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense.

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Ya-Ling Hou
Hsun-Shuo Chang
Hui-Chun Wang
Sheng-Yang Wang
Tze-Ying Chen
Chu-Hung Lin
Ih-Sheng Chen

Keywords

Abstract

A new neolignan, (R)-( - )-sassarandainol (1), together with 10 known compounds (2-11), was isolated from the stem of Sassafras randaiense. The structures were determined by spectroscopic techniques. Among these isolates, γ-tocopherol (5), subamolide B (7) and β-sitosterone (9) exhibited moderate iNOS inhibitory activity on nitrite production induced (%) value of 30.51, 28.68 and 16.96, respectively.

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