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Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 2000-Dec

[Side effects after treatment with a-interferon in children with chronic viral hepatitis].

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H Zhang
X Yang
S Zhu

Keywords

Abstract

OBJECTIVE

This paper aimed at a long-term observation on side effects of alpha- IFN treatment in children with chronic viral hepatitis.

METHODS

A randomized trial of 261 alpha-IFN treated chronic hepatitis children (183 with hepatitis B, 78 with hepatitis C) in comparison with 114 adults was carried out to observe side effect of alpha-IFN treatment 5-6 years in average and 10 years the longest. Mean age of children was 8.7 years, with 203 males and 58 females.

RESULTS

Early stage side effects were low to moderate fever and endemic influenza symptoms, which in children were more less than in adults (P < 0.001). Side effects did not relate to viral pathogeny (HB or HC) and pathological changes (< or = G2, > or = G3) in child patient. Slightly poor appetite, slight hair loss, rash and tinnitus would disappear gradually needed no treatment. Serum Bil, Bun, Cr, T3, T4 and TSH were normal in all patients. There was no long-term side effects.

CONCLUSIONS

alpha-IFN treatment for viral hepatitis in children is safe.

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