[Study on the mechanism of glucose intolerance and insulin resistance in epidemic hemorrhagic fever].

Intravenous glucose tolerance test (ivGTT) and insulin releasing test (IRT) were performed in 32 cases with epidemic hemorrhagic fever (EHF). 23 patients had impaired glucose tolerance, 17 patients showed hyperinsulinemia in fasting state, 12 patients had flat insulin response curves and most patients had higher plasma levels of growth hormone (GH), cortisol (F), norepinephrine (NE) and epinephrine (E) in critical stage than in convalescent stage. These data suggest that in EHF there are disturbed glucose metabolism and insulin resistance due to decreased pancreatic B cell reservoir and increased insulin antagonists such as GH, F, NE, E etc. It is suggested that use of insulin in addition to intravenous glucose infusion may be beneficial to glucose utilization in EHF.