English
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Carbohydrate Polymers 2018-Dec

Synthesis, structural and in-vitro characterization of β-cyclodextrin grafted L-phenylalanine functionalized graphene oxide nanocomposite: A versatile nanocarrier for pH-sensitive doxorubicin delivery.

Only registered users can translate articles
Log In/Sign up
The link is saved to the clipboard
Sedigheh Borandeh
Amir Abdolmaleki
Samira Sadat Abolmaali
Ali Mohammad Tamaddon

Keywords

Abstract

To enhance graphene stability, drug loading capacity and biocompatibility, β-cyclodextrin (β-CD) was grafted onto graphene oxide (GO) using L-plenylalanine (Phe) as a linker. The doxorubicin (DOX) loading efficiency and capacity of GO-Phe-CD were 78.7% and 85.2%, respectively. The cone shaped cavity of CD acts as a host for DOX loading through inclusion complex formation. The GO-Phe-CD nanocarrier showed higher release ratio of DOX in acidic milieu of cancer cells. In addition, general cytotoxicity of the nanocarriers was examined by MTT assay and trypan blue dye exclusion in MCF-7 cell lines. It was established that the MTT assay was not an appropriate technique for predicting the cytotoxicity of graphene based nanocarriers due to the spontaneous formation of MTT formazan by these materials; leading to a false high biocompatibility. According to the trypan blue experiment, the GO-Phe-CD had significant cytocompatibility, and the DOX-loaded GO-Phe-CD had outstanding killing capability to MCF-7 cells.

Join our facebook page

The most complete medicinal herbs database backed by science

  • Works in 55 languages
  • Herbal cures backed by science
  • Herbs recognition by image
  • Interactive GPS map - tag herbs on location (coming soon)
  • Read scientific publications related to your search
  • Search medicinal herbs by their effects
  • Organize your interests and stay up do date with the news research, clinical trials and patents

Type a symptom or a disease and read about herbs that might help, type a herb and see diseases and symptoms it is used against.
*All information is based on published scientific research

Google Play badgeApp Store badge