Organic Letters 2019-Oct
Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities.
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Keywords
Abstract
Two guaianolide sesquiterpenoid tetramers named ainsliatetramers A and B were separated from Ainsliaea fragrans. Through spectroscopic analyses, especially the band-selective CT-HSQC and CT-HMBC techniques, the complex skeleton was constructed from four sesquiterpene units via three different linkages. A biosynthetic pathway was proposed featuring a Michael addition and a regular and a hetero-Diels-Alder cycloaddition. Both exhibited potent cytotoxicity against human cancer cell lines with IC50 values ranging from 2 to 15 μM.