International Journal of Reproductive BioMedicine 2019-Feb
The protective effects of Crocin on testopathy in fat-fed and streptozotocin-treated diabetic rats: An experimental study.
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Keywords
Abstract
Materials and Methods
In this experimental study, type II of diabetes mellitus was induced by high-fat diet and low dose of streptozotocin. Male Wistar rats (8 weeks, 150-200 gr, 18 rats; n= 6 per group) were divided into a control group (standard diet), diabetic group (streptozotocin+high-fat diet), and treatment group (High-fat diet+streptozotocin+Crocin at 20 mg/kg/day, i.p. for 60 days). After 60 days, animals were euthanized, testis and epididymis were dissected, and weights of testes and sperm count were analyzed. Hematoxylin-eosin-stained was done for histopathological examination. Blood samples were collected for the assessment of serum glucose and cholesterol.Results
High-fat diet and streptozotocin significantly increased the serum glucose and cholesterol levels as compared to the control group (p