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Bioorganic and Medicinal Chemistry Letters 2006-Oct

Vialinin B, a novel potent inhibitor of TNF-alpha production, isolated from an edible mushroom, Thelephora vialis.

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Chun Xie
Hiroyuki Koshino
Yasuaki Esumi
Jun-ichi Onose
Kunie Yoshikawa
Naoki Abe

Keywords

Abstract

A novel dibenzofuran compound designated vialinin B was isolated from dry fruiting bodies of an edible mushroom, Thelephora vialis, and potently inhibits TNF-alpha production in RBL-2H3 cells (IC(50)=0.02nM) and is a promising anti-allergic agent.

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