Journal of Diabetes Investigation 2020-Jan
Elevated serum glycated albumin and glycated albumin to hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study.
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Keywords
Abstract
AIMS/INTRODUCTION
To investigate the association of alternative glycemic measures-namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c ), and the GA/HbA1c ratio-with global brain and hippocampal atrophy in a general elderly Japanese population.RESULTS
The mean values of the TBV/ICV and HV/ICV ratios decreased significantly with elevating serum GA levels and GA/HbA1c ratio levels (all P for trend <0.05), but not with higher HbA1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits, and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding subjects with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA/HbA1c ratio levels, but not HbA1c , were closely associated with lower mean values of the TBV/ICV and HV/ICV ratios, irrespective of the presence or absence of diabetes mellitus.CONCLUSIONS
The present study suggests that higher serum GA and higher GA/HbA1c ratio are significantly associated with global brain and hippocampal atrophy.