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Bioinformation 2020

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.

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Rajagopal Ponnulakshmi
Veeraraghavan Vishnupriya
Surapaneni Mohan
Srinivasan Abilasha
Govindan Ramajayam
Periyasamy Vijayalakshmi
Manikkam Rajalakshmi
Jayaraman Selvaraj

Keywords

Abstract

It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.

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