Journal of the European Academy of Dermatology and Venereology 2020-Apr
PI3K/AKT/mTOR pathway activation in actinic cheilitis and lip squamous cell carcinomas.
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Keywords
Abstract
Lower lip squamous cell carcinoma (LLSCC) is one of the most common cancers of the head and neck1 . Actinic cheilitis (AC) is a potentially malignant disorder of the lip, and it is estimated that 3.07% of AC cases undergo malignant transformation2 . Lip carcinogenesis is directly associated with exposure to ultraviolet (UV) radiation and tobacco.1,2 The molecular circuitry involved in this process, however, remains poorly understood.