Two new compounds with anti-inflammatory activity from Alangium chinense

A new phenolic glycoside, chinenside A (1), and a new megastigmane glycoside, chinenionside A (2), together with twelve known compounds (3-14), were isolated from the roots of Alangium chinense. Their structures were deduced on the basis of extensive spectroscopic analyses and comparison with data reported in the literature. The anti-inflammatory activity in vitro of all 13 phenolic glycosides was evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. The compounds 1, 9, and 10 potentially inhibited the productions of nitric oxide (NO), prostaglandin (PEG₂), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6). Compound 1 (50 μM) showed stronger anti-inflammatory activity than Triptolide (TPL, 20 nm).

Keywords: Alangium chinense; anti-inflammatory activity; megastigmane glycoside; phenolic glycoside.