Ultra-sonication Assisted Synthesis of D-Glucosamine Based β-CD Inclusion complex and Its Application as an Aqueous Heterogeneous Organocatalytic System

For the first time, inclusion has been crafted between a carbohydrate based molecule and β-CD hydrophobic cavity for the asymmetric catalytic applications. This novel D-glucosamine based inclusion compound has been synthesized in high yields using innovative and proficient acoustic cavitation technology and well characterized by using various techniques, such as IR, NMR, UV, TGA, SEM and other spectroscopic techniques. It was observed that the inclusion of D-glucosamine derivative in hydrophobic cavity of β-CD increased its surface area and thermal stability. This catalytic system worked well in water for direct aldol reaction to afford the products in excellent yields with high diastereo- and enantio-selectivities.