16 hydroxyphorbol/neoplasms

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A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-deoxy-16-hydroxyphorbol.

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A new type of phorbol ester, which has a macrocyclic dicarboxylic acid diester structure, was isolated from the seed oil of Jatropha curcas L. (Euphorbiaceae). Based on the results of spectroscopic analyses of the compound and its chemical degradation products, its structure is proposed to be an

Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics.

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OBJECTIVE In 1988, we first reported the complete chemical structure of a new type of phorbol ester, abbreviated to DHPB, found in seed oil of Jatropha curcas L. (Saboodam in Thai) and its tumor-promoting activity on mouse skin. Although this seed oil contains toxic phorbol ester, it was planned to

Cocarcinogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curaçao.

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From the roots of Croton flavens L., 3 highly irritant and tumor promoting Croton factors F1--F3 and the corresponding 3 cryptic Croton factors F'1--F'3 were isolated and characterized as novel esters of 16-hydroxy- and 4-deoxy-16-hydroxyphorbol, respectively. These findings suggest that tumor

On the active principles of the spurge family (Euphorbiaceae). V. Extremely skin-irritant and moderately tumor-promoting diterpene esters from Euphorbia resinifera Berg.

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The irritant and tumor-promoting principles were isolated from the latex of Euphorbia resinifera Berg. and from the resin derived from latex (euphorbium), which is commercially available as a drug. The irritant Euphorbia factors RL 5 (mixture), RL 6, RL 7, RL 8, and RL 10 were identified as

Molecular mechanisms of tumor promotion and multistage carcinogenesis.

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Carcinogenesis is a multistep process resulting from a complex interaction between multiple factors, both environmental and exogenous. In contract to initiating agents that act by damaging cellular DNA, the primary targets of the phorbol ester tumor promoters are membrane-associated receptors. We

Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium.

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We have found that maximum stimulation (greater than 10-fold) of kinase activity of a bovine brain preparation of calcium- and phospholipid-dependent protein kinase (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) occurs in the presence of phospholipid, but in the absence of added Ca2+. In

Distribution and characterization of environmental promoter substances as assayed by synergistic Epstein-Barr virus-activating system.

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The application of a new screening procedure which utilizes the synergistic effect of short-chain fatty acids and tumor-promoting diterpene esters enabled rapid and easy detection of environmental substances with Epstein-Barr virus (EBV)-activating/tumor-promoting potency. Over 500 samples were

Plant-derived diterpene esters enhance HTLV-I-induced colony formation of lymphocytes in co-culture.

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The addition to culture dishes of 10-50 ng/ml of the essential diterpene ester of Sapium sebiferum, 12-O-hexadecanoylphorbol-13-acetate (HPA), increased colony formation of normal peripheral blood lymphocytes co-cultured with gamma-irradiated HTLV-I-producing HUT 102 cells. The cells in the

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