2 3h benzothiazolone/hyperalgesia

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Synthesis and pharmacological evaluation of analgesic 6-substituted 2(3H)-benzothiazolones.

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A series of novel 6-substituted-2(3H)-benzothiazolones were synthesized and studied as analgesic agents. Among these compounds, two of them were found to exhibit potent analgesic activity in several in vivo tests (acetic acid writhing, Koster, carrageenan and PGE2 hyperalgesia). In these tests the

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