4 amino butyric acid/headache

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Pregabalin in acute and chronic pain.

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Pregabalin is a gamma-amino-butyric acid analog shown to be effective in several models of neuropathic pain, incisional injury, and inflammatory injury. In this review, the role of pregabalin in acute postoperative pain and in chronic pain syndromes has been discussed. Multimodal perioperative

Intrathecal midazolam as supplementary analgesia for chronic lumbar pain--15 years' experience.

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BACKGROUND The antinociceptive effect of intrathecal midazolam is based on its affecting spinal gamma-amino butyric acid receptors. OBJECTIVE To evaluate pain relief in patients with chronic low back pain and failed back surgery syndrome after a single-shot intrathecal administration of

Migraine: current therapeutic targets and future avenues.

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Migraine is characterized by attacks of intense pulsatile and throbbing headache, typically unilateral in nature with or without aura. Migraine affects a substantial fraction (10-20 %) of the world population (more women than men). With regard to the pathophysiology of migraine, several theories

Migraine: current concepts and emerging therapies.

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Migraine is a recurrent incapacitating neurovascular disorder characterized by attacks of debilitating pain associated with photophobia, phonophobia, nausea and vomiting. Migraine affects a substantial fraction of world population and is a major cause of disability in the work place. Though the

Sodium oxybate for the treatment of fibromyalgia.

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BACKGROUND Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that is synthesized within the CNS, mostly from its parent compound gamma amino butyric acid (GABA). GHB acts as a neuromodulator/neurotransmitter to affect neuronal activity of other neurotransmitters and so, stimulate the release

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