Bolus of intravenous lidocaine of 2mg/kg over 5 mins will be given before skin incision.

Normal Saline of 2mg/kg over 5 mins will be given as bolus before skin incision

Acute Pain

Bolus of lidocaine will be given over 5 minutes before skin incision

Lidocaine

Bolus of saline will be given over 5 minutes before skin incision

Saline

Queen Mary Hospital

Intravenous Lidocaine in Total Knee Replacement

NRS pain scores (from 0-10, where 0 is the least satisfaction and 10 most satisfaction) will be recorded during movement and at rest, by NRS (movement) and NRS (rest) respectively

Active and Passive ROM of knee (flexion and extension) will be recorded.

Walking Distance, degree of assistance, and need for aids

Dressing trousers, toileting will be recorded

Nausea, vomiting, dizziness, constipation

Dr. Chi-Wai Cheung

Clinical Professor

The University of Hong Kong

Subjects randomized into the control group will not receive study medication, they will receive a placebo administered at the same schedule as the active drug in the other arm.

Subjects randomized into the active treatment group will receive intravenous acetaminophen

Subjects randomized into the control group will not receive study medication, they will receive a placebo administered at the same schedule as the active drug in the other arm.
Placebo: Subjects randomized to placebo will receive every 6 hours for a total of 4 doses; first dose to be administered after induction of general anesthesia

Placebo

Subjects randomized into the active treatment group will receive intravenous acetaminophen
intravenous acetaminophen: administration of 1000mg of intravenous acetaminophen or placebo every 6 hours for a total of 4 doses; first dose to be administered after induction of general anesthesia

Acetaminophen IV

Total

Sex: Female, Male

Race/Ethnicity, Customized

Region of Enrollment

Height (cm)

Weight (kg)

Survey asking 15 questions with regard to how the patient is feeling scored on a scale from 0-10, with 0 being none of the time and 10 being all of the time. Possible scores range from 0-150, and scores with a higher value indicate a better outcome. Each subject was administered a baselineQoR-15 survey prior to surgery, and then one on postoperative days (POD) 1 and 2. If a subject was discharged prior to POD2, they were not given a QoR-15 survey that day.

Quality of Recovery-15 Patient Survey

Monitoring the length of hospital stay after undergoing surgery

Length of Hospital Stay

Accessing billing codes/hospital costs for each enrolled subject from the time they are admitted until they are discharged from the hospital.

Hospital Costs

Overall Study

Farrell Cooke, Senior Research Assistant

Obesity

administration of 1000mg of intravenous acetaminophen or placebo every 6 hours for a total of 4 doses; first dose to be administered after induction of general anesthesia

intravenous acetaminophen

Subjects randomized to placebo will receive every 6 hours for a total of 4 doses; first dose to be administered after induction of general anesthesia

Weill Cornell Medical College

Prospective, Double Blind, Placebo Control, Bariatric IV Ace

Prospective, Double Blind, Placebo Control, Study of Acetaminophen iv on Hospital Length of Stay in Morbidly Obese Individuals Undergoing Elective Laparoscopic Sleeve Gastrectomy

acetamide/nausea

Intravenous Lidocaine in Total Knee Replacement

Prospective, Double Blind, Placebo Control, Bariatric IV Ace

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