acidic peptide/hypoxia

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Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells.

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Endothelin-1 (ET-1) is a 21-amino acid peptide synthesized by several cell types in the lung. Locally, ET-1 regulates vascular and airway tone and is mitogenic for vascular and airway smooth muscle cells. Little, however, is known about the regulation of ET-1 in pulmonary endothelial cells. Cultured

[Status of cell membrane enzymes in hypoxia and the protective effect of pyrazidole].

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The influence of hypobaric hypoxia simulating the altitude of 9000 m above the sea level during 3 hours on the stability of erythrocyte, lysosomal, and mitochondrial membranes, has been studied. The increase in extra erythrocyte hemoglobin and free iron concentrations and the total peroxidase

Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing.

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The hypoxia-inducible factor 1 complex (HIF-1) is involved in the transcriptional activation of several genes, like erythropoietin and vascular endothelial growth factor, that are responsive to the lack of oxygen. The HIF-1 complex is composed of two b-HLH proteins: HIF-1beta that is constitutively

[Effects of oxygen deficiency on rat brain peptide-hydrolase activity with and without hypothermia].

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The effect of acute oxygen deficiency on the rat brain peptide-hydrolases (EC 3.4) activity was studied under conditions of acute hypoxic hypoxia (the pressure in altitude chamber 240 mm Hg) with concomitant hypothermia (--5.8 degree C) and without it. The activity of neutral peptide hydrolases

Adrenomedullin dilates rat pulmonary artery rings during hypoxia: role of nitric oxide and vasodilator prostaglandins.

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Hypoxia decreases vasorelaxation and leads to pulmonary arterial hypertension. A newly identified 52 amino-acid peptide adrenomedullin (ADM) exerts vasodilator effect in intact animals under normoxic condition. We studied the effect of human ADM on rat pulmonary arterial and aortic rings under

Sequence analysis of diamine oxidase gene from fava bean and its expression related to γ-aminobutyric acid accumulation in seeds germinating under hypoxia-NaCl stress.

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BACKGROUND γ-Aminobutyric acid (GABA) is synthesized via the polyamine degradation pathway in plants, with diamine oxidase (DAO) being the key enzyme. In this study the cDNA of DAO in fava bean was cloned and its expression in seeds germinating under hypoxia-NaCl stress was

The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours.

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DEC1, also known as SHARP-2 or Stra13, is an important molecule in embryonic differentiation and has recently been identified to be strongly inducible by hypoxia. Its distribution in normal human tissues and most tumour types is unknown. In the present study, a polyclonal antiserum to a 10-amino

Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase.

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Hypoxia-induced reactive oxygen species (ROS)-mediated expression of a variety of genes in endothelial cells has been suggested to be involved in abnormal cell adhesion. To prevent this by accelerated binding of catalase to endothelial cells, human catalase (hCAT), an enzyme catalyzing the

Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia.

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Chronic exposure in a low-PO(2) environment (i.e., chronic hypoxia, CH) elicits an elevated hypoxic ventilatory response and increased hypoxic chemosensitivity in arterial chemoreceptors in the carotid body. In the present study, we examine the hypothesis that changes in chemosensitivity are

Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia.

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Adrenomedullin is a 52 amino acid peptide that shows a remarkable range of effects on the vasculature that include inter alia, vasodilatation, regulation of permeability, inhibition of endothelial cell apoptosis, and promotion of angiogenesis. Recently the G-protein coupled receptor (GPCR)

Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension.

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Experimental pulmonary hypertension induced in a hypobaric hypoxic environment (HHE) is characterized by structural remodeling of the heart and pulmonary arteries. Endothelin-1 (ET-1), a 21-amino acid peptide, is a novel and long-lasting vasoconstrictor that increases pulmonary arterial pressure in

Vascular activities of the endothelins.

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The endothelins are a family of novel 21 amino-acid peptides and are the most potent vasoconstrictor substances yet discovered. The endothelins not only produce prolonged pressor responses in intact animals but they also constrict large and small arterial and venous vessels studied as isolated

Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus.

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Galanin is a 29-amino acid peptide widely distributed in the central nervous system where it modulates the release of several neurotransmitters and neurohormones. Because previous data had postulated that galanin could inhibit the release of excitatory amino acids and protect hippocampal neurons

Endothelin, vascular hypertrophy, and hypertension.

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The endothelins (ET-1, 2, and 3) constitute a family of 21 amino-acid peptides with potent biological activities. They are synthesized in several tissues, including the vascular endothelium (ET-1 exclusively) and smooth muscle cells. The production and release of endothelin is stimulated by many

Endothelin peptides: biological activities, cellular signalling and clinical significance.

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Endothelins (ET-1, ET-2 and ET-3) are a family of 21 amino acid peptides produced by endothelial cells. They are thought to regulate the local vasomotor tone with endothelium-derived relaxing factors. ETs are the most potent vasoconstrictor substances yet identified and veins and renal vasculature

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