aeschynomene aspera/tyrosine

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20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance

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20-HETE, a metabolite of arachidonic acid produced by Cytochrome P450 (CYP) 4A/4 F, has been implicated in the development of obesity-associated complications such as diabetes and insulin resistance. In this study, we examined whether the acute elevation of 20-HETE levels contributes to the

HIGH FAT DIET-INDUCED OBESITY AND INSULIN RESISTANCE IN CYP4A14-/- MICE IS MEDIATED BY 20-HETE.

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20-hydroxyeicosatetraenoic acid (20-HETE) has been shown to positively correlate with body mass index, hyperglycemia and plasma insulin levels. This study seeks to identify a causal relationship between 20-HETE and obesity-driven insulin resistance. Cyp4a14-/- male mice, a model of 20-HETE

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