akebia quinata/leukemia

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[Study on the mechanism of akebia saponin D for leukemia].

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OBJECTIVE To investigate the mechanism of akebia saponin D (ASD) for fight against leukemia cells. METHODS The human acute leukemia cell strain U937 and human acute promyelocytic leukemia cell strain HL-60 were treated with ASD at different doses (10, 30, 50, and 100 microg/mL). The proliferation

Apoptosis-inducing effect of akebia saponin D from the roots of Dipsacus asper Wall in U937 cells.

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Methanol extracts of the root of Dipsacus asper Wall (Dipsacaceae) were found to exhibit apoptosis-inducing activities in U937 (human monocyte-like histiocytic) cells. Investigation of the active n-BuOH fraction led to the isolation of akebia saponin D (ASD). Structure was established by

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