alangium longiflorum/hypoxia

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Separation and SAR study of HIF-1alpha inhibitory tubulosines from Alangium cf. longiflorum.

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A crude organic solvent extract of Alangium cf. longiflorum exhibited potent inhibition of hypoxia-induced HIF-1 transcriptional activity in human U251 glioma cells. Dereplication and bioactivity-guided fractionation, including Sephadex LH-20 and chiral HPLC chromatographies, led to the isolation of

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