alexander disease/staurosporine

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Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis.

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To get new insights into the function of the intermediate filament (IF) protein vimentin in cell physiology, we generated two mutant cDNAs, one with a point mutation in the consensus motif in coil1A (R113C) and one with the complete deletion of coil 2B of the rod domain. In keratins and glia

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