alkaloid/sarcoma

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Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines.

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Preparations from Uncaria tomentosa, a South American Rubiaceae, have been used in the Peruvian traditional medicine for the treatment of infective, inflammatory and tumoral processes. In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated from the dried inner bark of this plant

The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells

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The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J

In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.

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Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines. In the

In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species.

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Many authors have already emphasized that phytochemicals from spices have biological applications. Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. The aim of this study was to investigate the in vitro and in vivo antitumor effects of piperlonguminine in

Experimental studies on chemotherapy of malignant growth employing Yoshida sarcoma animals. XI. Effect of quinone derivatives, antibiotics, alkaloids, organoarsen, and other miscellaneous compounds.

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[The cell-killing kinetics of antimetabolites and Vinca alkaloids against in vitro cultured Yoshida ascites sarcoma cells (author's transl)].

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Kaposi's sarcoma. Local management with the vinca alkaloids.

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[Effects of a para-alkaloid of Colchicum autumnale on Galliera sarcoma of the rat].

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Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity

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The curiosity and attention that researchers have devoted to alkaloids are due to their bioactivities, structural diversity, and intriguing chemistry. Marine-derived macrocyclic alkaloids (MDMAs) are considered to be a potential source of drugs. Trabectedin, a tetrahydroisoquinoline derivative, has

Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma.

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Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma associated with infection by Kaposi sarcoma-associated herpes virus (KSHV). PEL is an aggressive disease with extremely poor prognosis when treated with conventional chemotherapy. Narciclasine, a natural product present in

Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-kappaB pathway.

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Primary effusion lymphoma (PEL) is a unique and recently identified non-Hodgkin's lymphoma that was originally identified in patients with AIDS. PEL is caused by the Kaposi sarcoma-associated herpes virus (KSHV/HHV-8) and shows a peculiar presentation involving liquid growth in the serous body

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.

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It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid,

[Effect of vincristine on Mg2+-ATPase activity of actomyosin-like protein from sarcoma-45 and actomyosin from rat skeletal muscle].

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Kinetic parameters of the inhibitory effect of vincristine on Mg2+ATPase activity containing in the actomyosin-like protein from rat sarcoma 45 and in actomyosin from rat skeletal muscle was studied. The alkaloid decreased the VM value for the reaction catalyzed by ATPase in presence of Mg2+ and

Phase II study of topotecan (NSC 609 699) in patients with recurrent or metastatic soft tissue sarcoma.

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BACKGROUND New drugs are needed for treatment of unresectable or metastatic soft tissue sarcoma. Topotecan, a semisynthetic derivative of the alkaloid, camptothecin, exerts its cytotoxic effect through inhibition of topoisomerase I. METHODS Thirty-two adult patients with locally advanced or

Experience of the use of trabectedin (ET-743, Yondelis) in 21 patients with pre-treated advanced sarcoma from a single centre.

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OBJECTIVE Trabectedin (ET-743, Yondelis) is a marine-derived alkaloid that has two actions. It binds in the minor groove of DNA resulting in a conformational change; thus potentially altering interactions with transcription factors and other DNA binding proteins and it also interacts with the

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