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allopurinol/inflammation

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Management of Prostatodynia in Younger Patients With Non-ablative Erbium:YAG Intraurethral Laser

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Prostatitis is the most common diagnosis (>50%) in men visiting outpatient urological clinics . The NIH classification classifies prostatitis into 4 types: category I - acute bacterial prostatitis, which is very rare, affecting only up to 5% of patients; category II- chronic bacterial prostatitis,

Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms

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One of the most common clinical presentations associated with coronary artery disease (CAD) is stable angina, which can be translated clinically into chest discomfort (or equivalent) evoked by different levels of physical activity depending on the extent of the disease. In the United States, it is

Study of Verinurad in Heart Failure With Preserved Ejection Fraction

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Evidence shows independent associations between hyperuricaemia and the risk of cardio-renal conditions, including heart failure (HF). Serum uric acid (sUA) is also a strong prognostic factor and correlates with other markers of poor prognosis in HF patients with preserved ejection fraction (HFpEF),

The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients:A Prospective Cohort Study

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1. Research drugs. Three kinds of uric acid lowering drugs, allopurinol, febuxostat and benzbromarone, will be evaluated in this study. 2. Study design and sample size calculation. This study was designed as a single-center prospective cohort study. Age-matched sperm donors from the human sperm bank

Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms

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Gout is the most prevalent inflammatory rheumatological disease among young men, affecting about 4% of the general population. Caused by the deposit of monosodium urate (MSU) crystals which form because of high urate concentrations in serum. Currently, there is no universal definition for

A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and Hyperuricaemia

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Evidence shows independent associations between hyperuricaemia and the risk of hypertension, myocardial infarction, chronic kidney disease (CKD), type 2 diabetes, heart failure, and metabolic syndrome, including obesity Furthermore, gout, an inflammatory arthritis caused by deposition of monosodium

Uric Acid Reduction as a Novel Treatment for Pediatric Chronic Kidney Disease

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Uric acid levels often rise when kidney function declines. Historically, high uric acid has not been treated unless the uric acid crystallizes in the joint space and causes clinical gout disease, more typically seen in adults. However, new research has shown that high uric acid levels are associated

Allopurinol in Acute Coronary Syndrome

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Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acid

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Sedentary, overweight and obese subjects diagnosed with T2D, ages 40-75 years old, will be recruited from the local community, via the University of Missouri's Endocrinology Clinic and the primary care clinics. During screening, and after consent, anthropometrics (waist circumference and body

Allopurinol in Diabetes Mellitus and Multivessel Coronary Artery Disease

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This is a pilot study, PROBE design (prospective randomized open label blinded endpoints study), that will include 100 patients. Patients will be recruited during their hospitalization in the cardiology department of Ichilov- Tel-Aviv Sourasky Medical Center. It will include patients with known or

Gout: Allopurinol vs. Febuxostat

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Gout is the most common form of inflammatory arthritis affecting adults (1), with a disease frequency that continues to increase dramatically (2). Gout is associated with substantial morbidity and mortality which are concentrated in older men and magnified in patients with chronic kidney disease

Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

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Diabetic nephropathy is characterized not only by glomerular disease but also tubulointerstitial injury. The tubular changes associated with diabetic nephropathy, include basement membrane thickening, tubular hypertrophy, epithelial-mesenchymal transition, glycogen accumulation and interstitial

Vitamin D and the Free Hormone Hypothesis

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Introduction: Vitamin D is a versatile signaling molecule with a well-established role in the regulation of calcium homeostasis and bone health. The spectrum of vitamin D target-organs has expanded and it has been suggested that vitamin D influences the immune system, endocrine organs such as

Prednisone for Heart Failure Patients With Hyperuricemia

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Hyperuricemia in heart failure (HF) is linked to renal impairment, hemodynamic compromise, and inflammation. Hyperuricemic HF patients are characterized by worsening of renal function and fragile volume state, both of which restrict the use of non-steroidal anti-inflammatory drugs (NSAIDs) when

A Pilot Study of Allopurinol As A Modifier of 6-MP Metabolism in Pediatric ALL

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- Patients will have several visits to the Pediatric Oncology outpatient clinic. Each visit will consist of a physical examination and laboratory evaluation. Each laboratory evaluation will consist of taking approximately 10 to 15 milliliters of blood (or approximately three teaspoons). These clinic
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