Patients who will be randomized to the control group will be waiting for the ET procedure without any intervention and without any deviation from the standard of care

Exposure to virtual reality environment exposure

IVF Outcomes

Stress Levels

Patients randomized to the study group, will be provided with the VR headset and sensors. The VR exposure will take place before the ET procedure, during their routine pre-transfer waiting period, in a private room. The patient will be able to choose between three different calming VR environments (3 scenes: beach sunset, palm tree patio or redwood forest) and will be exposed to the chosen VR environment for a continuous duration of 15-30 minutes. The VR exposure will be passive, and the patient can control her observation inside the environment by herself, simply by moving her head. During this period, at any time and for any reason, the patient can discontinue the use of the VR session simply by self-removing the helmet

Virtual reality

Create Fertility Centre

Virtual Reality Use in Assisted Reproductive Technology

The Use of Virtual Reality Technology in Infertile Women Undergoing in Vitro Fertilization-embryo Transfer: A Randomized Controlled Trial

The difference in CPR (determined by sonographic evidence of a gestational sac and fetal heart rate at 6 weeks' gestation by transvaginal ultrasound) between the study and the control group. An increase of 15% in the clinical pregnancy rate in the study group will be considered as significant.

Will be assessed using the STAI questionnaire (scored 20-80 points). We are expecting a 25% decrease in the STAI scores in the study group to be significant, based on clinical experience with similar patient population

Salivary samples will be collected and analyzed. A 30% decrease in the SAA levels in the study group vs control will be considered significant, based on a previous study

Heart rate & blood pressure measurements. These 2 sympathetic nervous system variables were selected as physical parameters which may indicate anxiety. A significant change between the groups will be based on clinical experience with similar patient populations. An estimated one-third (33%) of the patients would experience elevated blood pressure and/or heart rate readings in the moderate-to-severe range during the standard procedure. VR exposure therapy is expected to reduce this proportion to 20%.

Dr cliff Librach

Clifford Librach, MD, FRCS(C), FACOG(REI), Director of the Create Fertility Centre, Professor, Department of Obstetrics and Gynecology, University of Toronto

The Physician performing the embryo transfer will be blinded to the patient's group randomization

Proprietary Botanical Blend - Dietary supplement with alpha amylase and sucrase inhibitory activity. 2 capsules

Non/minimally nutritive nonactive material: rice flour. 2 capsules

Hyperglycemia

Carbohydrate

Insulin Resistance

Malabsorption

Oral administration of capsules containing proprietary botanical blend 30 minutes prior to carbohydrate ingestion.

Proprietary Botanical Blend

Oral administration of capsules containing rice flour (placebo) 30 minutes prior to carbohydrate ingestion.

Placebo

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption in Overweight, Insulin Resistant Adult Men and Women

Plasma glucose concentrations after the ingestion of a high carbohydrate meal

Measurement of hydrogen in exhaled air as an indicator of carbohydrate absorption

Plexus Worldwide

Participants will receive both treatments in random order with a washout period of at least 1 week between the 2 study visits. Women will be measured during the follicular phase of the menstrual cycle.

Treatment and placebo will be matched closely in color and appearance administered in a double blinded fashion as provided by the material supplier.

alpha amylase/stroke

Virtual Reality Use in Assisted Reproductive Technology

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption

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