alpha globulin/necrosis

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Alpha-globulins suppress human leukocyte tumor necrosis factor secretion.

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The secretion of tumor necrosis factor (TNF) by human peripheral blood mononuclear cells was suppressed by either whole human plasma alpha-globulins or purified alpha 1-acid-glycoprotein, alpha 1-antitrypsin and alpha 2-macroglobulin in a concentration-dependent manner. alpha 1-Antitrypsin was found

Purification and physico-chemical characterization of rabbit tumor necrosis factor.

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Rabbit TNF has been purified 2000-fold by a series of salt precipitations, gel filtrations, ion exchange chromatography, and lectin affinity chromatography to a single species on SDS-polyacrylamide gel electrophoresis (SDS-PAGE). TNF activity could be recovered from nondenaturing gel systems and has

Effect of anti-tumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections.

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We reported that administration of anti-tumor necrosis factor alpha (anti-TNF-alpha) antibodies exacerbates the course of a Salmonella infection in both susceptible and resistant mice by preventing the suppression of bacterial growth in the reticuloendothelial system. In the present study, we

Partial purification of a serum factor that causes necrosis of tumors.

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Tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus Calmette-Guérin and given bacterial endotoxin. Sera from normal mice, endotoxin-treated mice, and mice infected with bacillus Calmette-Guérin

Regulation of tumor necrosis factor secretion in leukocytes from alpha-1-antitrypsin deficient humans.

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Alpha-1-antitrypsin (AT) is one of several alpha-globulins which have been shown to be inhibitors of human peripheral blood monocyte TNF secretion in vitro. AT deficiency states exist, within which individuals of either the PiSS or PiZZ phenotype have reduced hepatocyte and mononuclear phagocyte AT

[A discussion on diagnosis and typing of viral hepatitis].

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OBJECTIVE To bring forward a suggestion about clinical diagnostic standard and clinical typing for chronic and severe hepatitis. METHODS To make a comprehensive study on clinical features and pathology of 895 cases of severe and chronic hepatitis, liver cirrhosis after hepatitis based on the viral

Age-associated changes in the immune system of German shepherd dogs.

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In order to look into the ageing of the canine immune system we investigated age-related changes and associated gender-related differences in parameters of innate and acquired immunity in German Shepherd dogs. We obtained the following findings: white blood cell counts, peripheral blood lymphocytes,

Rice-derived peptide AAGALPS inhibits TNF-α-induced inflammation and oxidative stress in vascular endothelial cells.

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Injury of vascular endothelial cell is one of the main factors triggering atherosclerosis. Peptide AAGALPS was derived from digestion and absorption product of rice α-globulin, which was proved to prevent atherosclerosis in previous study. This study aims to investigate the potential effects of

[A Shetland pony with a squamous cell carcinoma of the stomach].

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A 12-year-old Shetland pony was referred because of weight loss over several months and symptoms of colic. On rectal examination, enlarged mesenteric lymph nodes and an abnormal mass in the left anterior abdominal cavity were palpated. Haematological evaluation revealed leucocytosis (13 G.l-1) and

[The experimental studies on Capillaria hepatica]

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Capillaria hepatica is an extremely common parasite of rats. Several human cases have also been reported from various parts of the world and recently these aroused the clinical interests. The present study was undertaken to investigate the biological observations of C. hepatica and the changes

Differential effects of copper and zinc on human peripheral blood monocyte cytokine secretion.

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The addition of copper and zinc salts to human peripheral blood leukocytes cultured in complete medium containing endotoxin and fetal calf serum stimulated tumor necrosis factor (TNF) secretion in a concentration-dependent manner. The secretion of interleukin-1 beta (IL-1 beta) and interleukin-6

Inflammatory fluids regulate TNF-alpha, but not IL-1 beta, production by human peritoneal macrophages. A study of patients on continuous ambulatory peritoneal dialysis with peritonitis.

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To gain insight into the factors regulating an inflammatory response in vivo, the activities of peritoneal macrophages and the influence of the inflammatory fluids from which they were harvested were studied in continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis. Specifically,

Serum biochemistry profile, inflammatory cytokines, adipokines and cardiovascular findings in obese dogs.

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The aim of this study was to evaluate the serum biochemistry profile, inflammatory cytokines, adipokines and cardiovascular findings in obese dogs. Twenty obese and 20 normal weight healthy pet dogs were recruited into the study, where they underwent blood testing and assessment of cardiovascular

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