alpha globulin/neoplasms

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Alpha-globulins in the surveillance of colorectal cancer.

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The alpha1 and alpha2-globulins have been studied at various stages in the evolution of colo-rectal cancer. The alph2 was elevated in some primary tumours and rose in metastatic cancer especially when it involved the liver. Some apparently tumour free patients had an unexplained elevation of

[Amino-acid composition of serum leukocytes in health and disease. II. Structure of the total alpha-globulin in healthy individuals and in patients with acute inflammatory diseases, tuberculosis, nephrosis and malignant tumors].

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Immunochemical evidence of a tumor-specific surface antigen obtained by detergent solubilization of the membranes of a chemically induced sarcoma, meth-A.

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We reported previously the partial purification of detergent-solubilized specific tumor rejection antigen of a chemically induced sarcoma, Meth-A. During the course of the study, rabbit antiserum against a partially purified specific tumor rejection antigen preparation was raised and rendered

In vivo host immune to a tumor-specific transplantation antigen induced by Rous sarcoma virus.

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We examined the host immune response to a tumor-specific transplantation antigen (TSTA) induced by Rous sarcoma virus (RSV) In vivo. In contrast to previous in vitro studies, the present investigation demonstrated in vivo host immunity of the TSTA 10-55 days after tumor inoculation. Immunity to the

Quantitative change of serum protein and immunoglobulin in patients with solid cancers.

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There are many quantitative changes of serum protein and immunoglobulin fractions in patients with cancer of various sites, excluding those with leukemic and lymphoproliferative disorders. The commonest change in serum proteins of patients with neoplastic disease is a reduction in albumin

Immunological and plasma protein changes in cancer patients following a single plasmapheresis.

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Serial serum protein determinations and immunological monitoring were performed prior to and following a single 4 to 5 liter plasma exchange in 10 patients with disseminated cancer. The most consistent changes were observed for two initially elevated alpha globulins, acid glycoprotein and

The integration of new therapies and radiation in the management of ovarian cancer.

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New biologic information has led to a therapeutic program in Stage III ovarian cancer that considers the whole peritoneal cavity the tumor-bearing region and that uses intraperitoneal administration of ovarian cancer antiserum, intraperitoneal P-32, delayed split abdominal irradiation, and

Food preferences, nutrient intake and nutritional status in cancer patients.

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Food intake and nutritional status were estimated in 34 cancer patients (14 patients with non-Hodgkin lymphoma and 20 patients with relapse of different cancers) and 25 healthy subjects (control group). A two-month dietary history based on Burke's method was used to estimate food intake. Nutritional

Serum inhibitory factor for guinea pig macrophage and neutrophil chemotaxis found in cancer patients.

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The effect of sera from 107 patients with gastrointestinal cancer on macrophage chemotaxis was studied using a modified Boyden chamber technique. A macrophage chemotactic inhibitory factor (CIF) was found in sera of advanced cancer patients. The CIF activity was significantly stage-related, and

Biological and biochemical properties of Nonidet P40-solubilized and partially purified tumor-specific antigens of the transplantation type from plasma membranes of a methylcholanthrene-induced sarcoma.

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Tumor-specific transplantation antigen (TSTA) was solubilized from cell membranes of sarcoma Meth-A with non-ionic detergent Nonidet P40. Soluble TSTA was partially characterized by chromatographic separation and electrophoresis. The antigen responsible for tumor rejection activity had a molecular

Effect of anti-tumor necrosis factor alpha antibodies on histopathology of primary Salmonella infections.

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We reported that administration of anti-tumor necrosis factor alpha (anti-TNF-alpha) antibodies exacerbates the course of a Salmonella infection in both susceptible and resistant mice by preventing the suppression of bacterial growth in the reticuloendothelial system. In the present study, we

Partial purification of a serum factor that causes necrosis of tumors.

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Tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus Calmette-Guérin and given bacterial endotoxin. Sera from normal mice, endotoxin-treated mice, and mice infected with bacillus Calmette-Guérin

Rice-derived peptide AAGALPS inhibits TNF-α-induced inflammation and oxidative stress in vascular endothelial cells.

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Injury of vascular endothelial cell is one of the main factors triggering atherosclerosis. Peptide AAGALPS was derived from digestion and absorption product of rice α-globulin, which was proved to prevent atherosclerosis in previous study. This study aims to investigate the potential effects of

Genetically modified rice produces ginsenoside aglycone (protopanaxadiol).

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Protopanaxadiol is dammarane-type tetracyclic triterpene sapogenin found in ginseng and has a high medicinal values. We successfully constructed transgenic rice producing protopanaxadiol by introducing the ginseng PgDDS and CYP716A47 genes in this crop plant. Protopanaxadiol (PPD), an aglycone of

Direct effects of cytostatic therapy on the functional state of the thyroid gland and TBG in serum of patients.

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This study analysed the concentrations of thyroid binding globulin (TBG) in the serum as well as the level of triiodothyronine (T3), thyroxine (T4), thyreostimulating hormone (TSH), thyroglobulin (Tg) and T4/TBG coefficient, before therapy and on the fifth day of therapy in 27 patients of both sexes

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