alpha prostaglandin f 2/seizures

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Role of prostanoids in cerebrovascular responses during seizures in piglets.

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We examined the role of prostanoids to bicuculline-induced seizures in newborn pigs. Using the closed cranial window method and radioimmunoassay for prostanoids, we found that pial arterioles dilated during seizures; this dilation was associated with increased cortical periarachnoid cerebrospinal

2-decarboxy-2-hydroxymethyl prostaglandin E1 (TR4161), a prostaglandin bronchodilator of low tracheobronchial irritancy.

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2-Decarboxy 2-hydroxymethyl prostaglandin E1 (TR4161) relaxed isolated quinea-pig trachea with about double and relaxed human isolated bronchial muscle with about one half the potency of PGE1. In conscious restrained cats an aerosol of TR4161 was about 100-1000 times less active than PGE1 in

Determination of 9 alpha, 11 beta-prostaglandin F2 by stereospecific antibody in various rat tissues.

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In view of the recent finding that prostaglandin D2 is stereospecifically converted to 9 alpha, 11 beta-prostaglandin F2, an isomer of prostaglandin F2 alpha, a highly specific and sensitive radioimmunoassay for 9 alpha, 11 beta-prostaglandin F2 was developed and applied to determine the content of

Prostaglandin E1-induced latent epileptogenic foci.

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Suprafusion of 125 microliter 6% KCl solution over the visual cortex of rabbits 2-24 h after they suffered a prostaglandin (PG) E1-induced epileptic seizure was found to cause a recurrence of seizure activity. The initial seizure was induced by the cortical suprafusion of PGE1 over the left visual

Carboprost exposure in a newborn with recovery.

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BACKGROUND This case describes a newborn who was accidentally given carboprost (Hemabate) 250 micrograms intramuscularly, the largest amount ever reported in a normal newborn. METHODS A full-term newborn was inadvertently given carboprost rather than his prescribed hepatitis vaccine. Within 15

Selenium induced anticonvulsant effect: a potential role of prostaglandin E(1) receptor activation linked mechanism.

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METHODS Selenium deficiency has been associated with enhanced propensity of seizures in man and laboratory animals. Therefore, the present study has been designed to investigate the anti-convulsant effect of sodium selenite and seleno-dl-methionine on pentylenetetrazole induced seizures in mice and

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