alpha terpinene/hypersensitivity

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Tea tree oil: contact allergy and chemical composition.

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In this article, contact allergy to, and the chemical composition of, tea tree oil (TTO) are reviewed. This essential oil is a popular remedy for many skin diseases, and may be used as neat oil or be present in cosmetics, topical pharmaceuticals and household products. Of all essential oils, TTO has

Assessment of sensitization potential of monoterpenes using the rat popliteal lymph node assay.

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The popliteal lymph node assay (PLNA) has been proposed as a screening test for detecting chemicals with potential of inducing allergic and auto-immune-like reactions in humans. In the present study, we used the rat PLNA to evaluate the immuno-sensitizing potential of 10 monoterpenes found in the

In Chemico Evaluation of Tea Tree Essential Oils as Skin Sensitizers: Impact of the Chemical Composition on Aging and Generation of Reactive Species.

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Tea tree oil (TTO) is an essential oil obtained from the leaves of Melaleuca alternifolia, M. linariifolia, or M. dissitiflora. Because of the commercial importance of TTO, substitution or adulteration with other tea tree species (such as cajeput, niaouli, manuka, or kanuka oils) is common and may

What Happens after Activation of Ascaridole? Reactive Compounds and Their Implications for Skin Sensitization.

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To replace animal testing and improve the prediction of skin sensitization, significant attention has been directed to the use of alternative methods. The direct peptide reactivity assay (DPRA), the regulatory agencies' approved alternative in chemico method, has been applied for understanding the

Melaleuca oil (tea tree oil) dermatitis.

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BACKGROUND Melaleuca oil (tea tree oil) is the essential oil distilled from the leaves of Melaleuca alternifolia Cheel. Tea tree oil is popular for treating various cutaneous maladies. OBJECTIVE Our purpose was to determine which constituent compounds of Melaleuca oil are responsible for allergic

Degradation products of monoterpenes are the sensitizing agents in tea tree oil.

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BACKGROUND Patients using tea tree oil (TTO) topically may become sensitized to this natural remedy. More than 30 cases have been documented in the literature since 1991. OBJECTIVE Freshly distilled, as well as oxidized TTO, some fractions, and single constituents were used for experimental

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