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aminophylline/breast neoplasms

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Adenosine A2B receptor blockade slows growth of bladder and breast tumors.

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The accumulation of high levels of adenosine in tumors activates A(2A) and A(2B) receptors on immune cells and inhibits their ability to suppress tumor growth. Deletion of adenosine A(2A) receptors (A(2A)ARs) has been reported to activate antitumor T cells, stimulate dendritic cell (DC) function,

The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophylline.

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OBJECTIVE To investigate the effect of colony-stimulating factors (CSFs) on drug metabolism using theophylline as a substrate (phase I), and to evaluate the influence of theophylline on endogenous serum cytokine concentrations (phase II). METHODS Open-label, prospective study. METHODS The bone
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