aminophylline/fatigue

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Aminophylline and fatigue of the sternomastoid muscle.

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We examined the influence of intravenously infused aminophylline on the contractility of the sternomastoid muscle in 8 subjects. The muscle was stimulated directly using bipolar surface electrodes at 1, 10, 20, and 50 pulses per second (pps), and the force response was recorded. The ratio of force

Effect of aminophylline on fatigue of the sternomastoid muscle in man.

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The effect of intravenous aminophylline on the contractility of the sternomastoid muscle was measured in the fresh state and after the induction of significant fatigue in five normal subjects. Fatigue was produced by repetitive isometric neck flexion, for two seconds every four seconds at 70% of the

Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study.

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BACKGROUND Diaphragmatic fatigue may contribute to the development of respiratory failure. Although aminophylline administered IV has been widely used to treat diaphragmatic fatigue, to date it has not been used in aerosol formulation for this purpose. OBJECTIVE The aim of this study was to assess

Effects of aminophylline on diaphragmatic fatigue during acute respiratory failure.

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The effects of aminophylline on diaphragmatic fatigue and recovery in the face of hypoxemia and hypercapnic acidosis were studied in anesthetized, spontaneously breathing, dogs. The phrenic nerves were stimulated supramaximally at 10, 20, 50, and 100 Hz during 2 s with electrodes placed around the

Effect of aminophylline on high-energy phosphate metabolism and fatigue in the diaphragm.

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BACKGROUND Diaphragmatic fatigue causes respiratory failure, for which aminophylline has been used as therapy. Because the mechanism of action of aminophylline in reversing diaphragmatic fatigue is unclear, we used in vivo 31P magnetic resonance spectroscopy (MRS) to determine the relation between

Effect of aminophylline on muscle fatigue.

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The effects of two different concentrations of aminophylline, 50 microM/L and 500 microM/L on muscle fatiguability were tested using frog gastrocnemius-sciatic preparations. Two stimulation protocols, one high energy demand, and the other low energy demand were used to induce muscle fatigue. The

Chronic aminophylline administration. Effect on diaphragm contractility and fatigue resistance in vitro.

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The effects of acute and chronic administrations of aminophylline (AM) on diaphragm contractility and fatigue resistance were examined in 42 rats. In acute experiments (n = 22), the animals received an intravenous bolus of either AM (14 mg/kg; n = 11) or saline (n = 11). Serum AM level was

Aminophylline and fatigue of adductor pollicis in man.

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1. The effect of intravenous aminophylline on the contractility of adductor pollicis has been studied in three subjects both in the fresh state and following the induction of muscle fatigue. 2. Aminophylline had no influence on the frequency-force relationship and relaxation rate of adductor

[Effect of aminophylline on fatigue of inspiratory muscles].

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Effect of aminophylline on the fatigue of inspiratory muscles and ventilation disorders induced by respiratory resistive load was studied in cats. The administration of aminophylline on the background of inspiratory fatigue increases transdiaphragm pressure, restores bioelectric activity of

[Clinical controlled study of shenmai injection and aminophylline on diaphragm fatigue].

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OBJECTIVE To compare the therapeutic effect of Shenmai injection (SM) and aminophylline (AP) on diaphragm fatigue in chronic obstructive pulmonary disease (COPD). METHODS Sixty-four COPD patients with respiratory failure and diaphragm fatigue were randomly divided into 2 groups: (1) SM group (33

Effects of fatigue, fiber length, and aminophylline on human diaphragm contractility.

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The clinical relevance of methylxanthines as therapeutic agents for improving diaphragmatic contractility is controversial. In a double-blind, placebo-controlled trial, we investigated the effect of aminophylline on the contractility of fresh and fatigued human diaphragm at different lung volumes,

Effects of aminophylline on diaphragmatic fatigue during acute respiratory failure.

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[Experimental diaphragmatic muscle fatigue caused by elastic charge. Effect of aminophylline].

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Effects of aminophylline and terbutaline sulfate on the contractility of feline diaphragm.

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1. The effect of aminophylline and terbutaline sulfate, separately and in combination, on the contractility of the feline diaphragm was investigated. 2. Diaphragmatic contractility increased significantly (P less than 0.05) to 28.3% above control level as long as theophylline plasma levels were

Effect of methylxanthines on diaphragmatic fatigue in the piglet.

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Studies in adult animal and human subjects have suggested that the methylxanthine drugs can delay the onset or attenuate the severity of diaphragmatic fatigue. We have investigated the effect of aminophylline and caffeine on the pressure-generating capacity of the fatigued diaphragm in 1-mo-old

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