aminophylline/inflammation

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[Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease].

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OBJECTIVE To observe the role of aminophylline and simvastatin in preventing and curing chronic obstructive pulmonary disease (COPD), and to explore the underlying mechanisms based on airway inflammation and mucus hypersecretion. METHODS The rat model of COPD was established by combination of

Effects of inhaled aminophylline on airway constriction and inflammation in ovalbumin-sensitized guinea pigs.

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BACKGROUND The systemic administration of theophylline is useful for asthma treatment. However its narrow therapeutic range makes it difficult to use. Little is known about its potential in inhalation therapy, particularly repeated inhalation. OBJECTIVE The purpose of this study is to investigate

A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children.

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BACKGROUND Aminophylline, an established bronchodilator, is also purported to be an effective diuretic and anti-inflammatory agent. However, the data to support these contentions are scant. We conducted a prospective, open-label, single arm, single center study to assess the hypothesis that

Aminophylline and progesterone prevent inflammation-induced preterm parturition in the mouse.

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Although progesterone (P4) supplementation is the most widely used therapy for the prevention of preterm labor (PTL), reports of its clinical efficacy have been conflicting. We have previously shown that the anti-inflammatory effects of P4 can be enhanced by increasing intracellular cAMP levels in

ON THE ANTI-INFLAMMATORY ACTIVITY OF AMINOPHYLLINE.

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[The role of glucocorticosteroid and theophylline in asthmatic inflammation of murine model and the inhibition in NO production in lung].

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OBJECTIVE To investigate the role of glucocorticosteroid and theophylline in treatment of asthmatic inflammation and their effects in production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS). METHODS A murine model was set up (A group: asthma model, N group:

Aminophylline attenuates the edemogenic actions of histamine in the canine forelimb.

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Xanthines have been employed clinically to treat asthma and related pulmonary conditions because of their bronchodilator properties. In addition, xanthines have been reported to block and/or attenuate the increase in microvascular permeability to macromolecules produced by some putative inflammatory

Aminophylline increases respiratory muscle activity during hypercapnia in humans.

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Theophylline is an old drug traditionally used as a bronchodilator, although it was recently shown to possess anti-inflammatory properties, enhance the actions of corticosteroid actions, and stimulate the respiratory neuronal network. Theophylline has been recognized as an important drug for not

The inhaled administration of KF19514, a phosphodiesterase 4 and 1 inhibitor, prevents antigen-induced lung inflammation in guinea pigs.

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We examined in this study the effect of KF19514, a phosphodiesterase 4 and 1 inhibitor, on antigen-induced lung inflammation by inhaled administration in guinea-pigs. It was previously reported that inhaled KF19514 prevented antigen-induced bronchoconstriction and platelet-activating factor

Aminophylline for methotrexate-induced neurotoxicity.

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Methotrexate, a mainstay treatment for children with acute lymphoblastic leukaemia, can cause neurotoxicity, with paralysis, seizures, somnolence, anorexia, and headaches. The pathophysiology of this reaction is unknown. It has been suggested that the anti-inflammatory effect of methotrexate in

[Effect of shenmai injection and aminophylline on small airway smooth muscle cell apoptosis and related gene expression in rats with emphysema].

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OBJECTIVE To investigate the effect of Shenmai Injection (SMI) and aminophylline on small airway smooth muscle cell (SASMC) apoptosis and the Fas/FasL expression in the papain induced emphysema model rats. METHODS Emphysema model in rat was established by a single intratracheal instillation of

Effects of shenmai and aminophylline on apoptosis of small airway smooth muscle cells and the expression of relevant genes in rats with emphysema.

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The effects of Shenmai injection (SMI) and aminophylline on apoptosis of small airway smooth muscle cells (SASMC) and the Fas/FasL expression in rats with papain-induced emphysema were investigated. Rat emphysema model was established by a single intratracheal instillation of papain. Apoptosis and

Effects of aminophylline on cytokines and pulmonary function in patients undergoing valve replacement.

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OBJECTIVE This study is to evaluate the effects of aminophylline on systemic inflammatory response after cardiopulmonary bypass in patients undergoing valve replacement. METHODS Thirty patients undergoing elective valve replacement were randomized to receive either aminophylline treatment

[Protective effect of aminophylline on cerebral injury during cardiopulmonary bypass in infants].

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OBJECTIVE To investigate the protective effect of aminophylline on cerebral injury induced by cardiopulmonary bypass (CPB) in infants. METHODS Forty patients who underwent ventricular septal defect within 3 years old were randomly divided into 2 groups(20 cases in each group).Aminophylline

Pulmonary function changes and immunomodulation of Th 2 cytokine expression induced by aminophylline after sensitization and allergen challenge in brown Norway rats.

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OBJECTIVE Evidence has shown that aminophylline has bronchoprotective, anti-inflammatory, and immunomodulatory effects. Our purpose was to evaluate the effect of different doses of aminophylline on the late-phase reaction, bronchial hyperresponsiveness (BHR) and T cell-related cytokine mRNA

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