analgesic/cannabis

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Medical marijuana policies and hospitalizations related to marijuana and opioid pain reliever.

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Twenty-eight states in the U.S have legalized medical marijuana, yet its impacts on severe health consequences such as hospitalizations remain unknown. Meanwhile, the prevalence of opioid pain reliever (OPR) use and outcomes has increased dramatically. Recent studies suggested unintended impacts of

Perspectives on cannabis as a substitute for opioid analgesics.

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With the opioid epidemic reaching new heights in the USA, it has become critical to find suitable alternatives to opioids. Cannabis, an antinociceptive, is a strong contender to help patients reduce their opioid usage. A growing literature has been examining the complex effects cannabis has on pain

Marijuana and Prescription Pain Reliever Use among Cigarette Smokers.

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Due to marijuana's analgesic effects and its growing national legal status, it is likely that marijuana's rising prevalence will impact prescription pain reliever (PPR) use. The present study investigates the relationship between marijuana and PPR use among U.S. adult current cigarette smokers. Data

Association between Nonmedical Marijuana and Pain Reliever Uses among Individuals Aged 50.

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Marijuana and pain reliever use for medical and nonmedical purposes has been increasing among older adults. Using the 2012-2013 U.S. National Survey on Alcohol and Related Conditions (NESARC-III), this study examined: (1) the association between past-year nonmedical marijuana and pain reliever use

Therapeutic potential of cannabinoid receptor agonists as analgesic agents.

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Increasing data emerging from controlled clinical trials support an analgesic activity of cannabinoids. However, the psychotropic side effects associated with tetrahydrocannabinol or synthetic derivatives essentially puts a brake on their use, possibly limiting the degree of analgesia that can be

Nonmedical prescription pain reliever and alcohol consumption among cannabis users.

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BACKGROUND This study examined poly-drug use involving the use of cannabis with nonmedical prescription pain reliever use (NMPR) and alcohol use. METHODS Computer-assisted survey data from the National Survey on Drug Use and Health were examined. The NSDUH is an annual, cross-sectional survey of

[Analgesic effects of cannabinoids on central pain syndrome].

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It was shown that cannabinoids anandamide, HU210 and WIN 55,212-2 inhibit both spontaneous episodes of pain and mechanical allodynia in rats with central pain syndrome caused by disturbance of inhibitory processes in the dorsal horns of lumbar spinal cord. The analgesic effect is most pronounced in

A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis.

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A randomized, placebo-controlled crossover trial utilizing vaporized cannabis containing placebo and 6.7% and 2.9% delta-9-tetrahydrocannabinol (THC) was performed in 42 subjects with central neuropathic pain related to spinal cord injury and disease. Subjects received two administrations of the

Preliminary study of chronic pain patients' concerns about cannabinoids as analgesics.

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OBJECTIVE This was a preliminary investigation of patients' beliefs about cannabinoids and the associations between those beliefs, beliefs about medication, and personal and pain variables with regard to patients' willingness to try cannabinoids as analgesics. METHODS A self-completion questionnaire

Prescription Pain Reliever Use and Misuse among Cannabis Users Aged 50+ Years.

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Objectives: To examine rates and correlates of dual cannabis and prescription pain reliever (PPNR) use and misuse among U.S. individuals aged 50+ who reported past-year cannabis use.Methods: Using the 2015-2018 National Survey of Drug Use and Health, we examined cannabis nonuse/use and

[A novel analgesics made from Cannabis].

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Bayer AG has recently announced that it acquired exclusive rights for the marketing of GW Pharmaceuticals' new medicine Sativex in Europe and in other regions. Sativex is a sublingual spray on Cannabis extract basis, and is equipped with an electronic tool to facilitate accurate dosing and to

A molecular basis of analgesic tolerance to cannabinoids.

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Clinical usage of cannabinoids in chronic pain states is limited by their central side effects and the pharmacodynamic tolerance that sets in after repeated dosage. Analgesic tolerance to cannabinoids in vivo could be caused by agonist-induced downregulation and intracellular trafficking of

An analgesic role for cannabinoids.

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Cannabinoids have significant analgesic properties in animal models, particularly for chronic pain states, but there are few human studies. An endogenous cannabinoid system, with specific receptors and transmitters, has recently been discovered. This discovery has led pharmacologists to explore the

Cannabinoids as potential new analgesics.

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Among other pharmacological properties analgesia is one of the important features of cannabinoids with therapeutical prospects. Cannabinoids have been shown to produce antinociception in experimental animals and humans. Recently a new system of neuromodulation based upon the existence of cannabinoid

Psychotropic analgesic nitrous oxide prevents craving after withdrawal for alcohol, cannabis and tobacco.

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We investigated the anti-craving effect of psychotropic analgesic nitrous oxide (PAN) in both an urban and rural community. Our results show that PAN, effectively eliminates or reduces craving in both cohorts in 98% of cases reporting craving. This positive effect is extremely rapid occurring within

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