annickia/antimalarial

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Protoberberine alkaloids as antimalarials.

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The protoberberine alkaloids berberine (1), palmatine (2), jatrorrhizine (3), and several berberine derivatives (4-10) were tested for antimalarial activity in vitro against Plasmodium falciparum and in vivo against Plasmodium berghei. The berberine derivatives 4-10 were designed and synthesized to

Natural Products as Sources of Antimalarial Drugs: Ethnobotanical and Ethnopharmacological Studies

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Materials and methods: For this study, relevant information was procured from the inhabitants via a structured questionnaire to procure the general knowledge of antimalarial medicinal plants. Results and Discussion. A total of 90 interviewees (44 men and 46

Efficacy of Cymbopogon giganteus and Enantia chrantha against chloroquine resistant Plasmodium yoelii nigeriensis.

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The antimalarial activity of boiled water extracts of two medicinal plants (Cymbopogon giganteus and Enantia chlorantha) against chloroquine resistant Plasmodium yoelii nigeriensis in albino mice was assessed. Twenty-five mice were used for each extract. Each mouse was inoculated with approximately

Intervention of standardized ethanol leaf extract of Annickia polycarpa, (DC.) setten and maas ex I.M. turner. (Annonaceae), in Plasmodium berghei infested mice produced anti-malaria action and normalized gross hematological indices

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Ethnopharmacological relevance: Malaria is a global public health burden due to large number of annual infections and casualties caused by its hematological complications. The bark of Annickia polycarpa is an effective anti-malaria agent

In vivo antiplasmodial potentials of the combinations of four nigerian antimalarial plants.

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Various combinations of Nauclea latifolia root, Artocarpus altilis stem bark, Murraya koenigii leaf and Enantia chlorantha stem bark used in African ethnomedicine as decoctions for malaria and fevers, and combinations with standard drugs, were investigated for antiplasmodial activities using

Medicinal plants useful for malaria therapy in Okeigbo, Ondo State, Southwest Nigeria.

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There is increasing resistance of malaria parasites to chloroquine, the cheapest and commonly used drug for malaria in Nigeria. Artemisin, a product from medicinal plant indigenous to China, based on active principle of Artemisia annua, has been introduced into the Nigerian market. However not much

"Antimalarial" medicinal plants and their impact on cell populations in various organs of mice.

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We have investigated the effects of leaf and bark decoctions of Ocimum gratissimum, Azadirachta indica, Morinda lucida and Enantia chlorantha on (a) the course of Plasmodium yoelii nigeriensis malaria (b) reticulocyte and haematocrit values and (c) nucleated cell numbers in the spleen, bone marrow,

In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants.

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In a search for new plant-derived antimalarial extracts, 19 fractions were obtained from three Annonaceae species, Uvariopsis congolana (leaf, stem), Polyalthia oliveri (stem bark), and Enantia chlorantha (stem, stem bark) with yields ranging from 0.33% to 4.60%. The extracts were prepared from 500

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